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doi: 10.1038/ncomms11037 92 ZwiersAJde WildtSNHopWCDorresteijnEMGischlerSJTibboelDet al

Thiol group deficit (-SH)

Additionally, UA-induced activation of RAGE promotes the expression and extracellular release of high mobility group box 1 protein (HMGB1) by endothelial cells, lymphocytes, monocyte-derived macrophages, and vascular smooth muscle cells

The three scenarios described above are all classic symptoms of Parkinsons disease, which tends to occur more often in older people, but can certainly affect young patients as well.